Antibacterial Agents: Chemistry, Mode of Action, Mechanisms - download pdf or read online

By Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

ISBN-10: 0470972440

ISBN-13: 9780470972441

Antibacterial brokers act opposed to bacterial an infection both by means of killing the bacterium or via arresting its development. They do that by means of concentrating on bacterial DNA and its linked approaches, attacking bacterial metabolic procedures together with protein synthesis, or interfering with bacterial cellphone wall synthesis and function.

Antibacterial Agents is a necessary consultant to this crucial category of chemotherapeutic medicinal drugs. Compounds are organised in line with their goal, which is helping the reader comprehend the mechanism of motion of those medicines and the way resistance can come up. The publication makes use of an built-in “lab-to-clinic” strategy which covers drug discovery, resource or synthesis, mode of motion, mechanisms of resistance, scientific elements (including hyperlinks to present directions, major drug interactions, cautions and contraindications), prodrugs and destiny improvements.

Agents coated include:

  • agents concentrating on DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
  • agents focusing on metabolic tactics -  sulfonamide antibacterial brokers and trimethoprim
  • agents concentrating on protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
  • agents focusing on mobilephone wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin

Antibacterial Agents will discover a position at the bookshelves of scholars of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

Show description

Read Online or Download Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications PDF

Similar clinical chemistry books

New PDF release: Catalysts for Fine Chemical Synthesis. Microporous and

This sequence deals functional aid for complex undergraduate, graduate and postgraduate scholars, in addition to skilled chemists in and academia operating with catalysts in natural and organometallic synthesis. It positive factors demonstrated and demonstrated methods, authoritative reports on periods of catalysts, and tests of every kind of catalysts.

Bioorganometallics: Biomolecules, Labeling, Medicine - download pdf or read online

This primary finished booklet to hide the increasing box of bioorganometallics represents the right start line for newbies but additionally an exceptional resource of top of the range details for specialists within the box. Edited by means of a pioneer within the box with an outstanding status in the neighborhood, this ebook starts with the historical past of bioorganometallics, sooner than occurring to hide prescribed drugs, bioorganometallic chemistry and radiopharmaceuticals.

New PDF release: Bailey's industrial oil and fat products. / volume 1, Edible

First released in 1945, Bailey's has turn into the traditional reference at the nutrition chemistry and processing know-how on the topic of fit to be eaten oils and the nonedible byproducts derived from oils. This 6th version positive factors new insurance of suitable for eating fat and oils and is more advantageous by way of a moment quantity on oils and oilseeds.

Additional resources for Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Sample text

2004). MBLs, enzymes which hydrolyse the b-lactam ring of carbapenems through a mechanism involving zinc ion catalysis, have recently emerged in Enterobacteriaceae and represent the greatest threat to the use of these antibiotics. For example, the gene for the newest MBL, NDM-1 (blaNDM-1), was only characterised in 2008 (it originated in India and Pakistan), but NDM-1 positive isolates have now been detected all across the globe, including the USA, UK, Europe, and Australia. These isolates have been detected in patients who have visited India (in an age where air travel can take us and our infections anywhere in the globe within 24 hours, this is not surprising), often for surgery (Walsh, 2010).

The fact that these agents are bactericidal rather than bacteriostatic is more difficult to address and is unlikely to be due to the inhibition of DNA synthesis, as the concentration of a quinolone required to block DNA synthesis is much lower than that required to kill cells. 6) (Froehlich-Ammon and Osheroff, 1995). Such double-strand DNA breaks, when generated by other means, are known to be lethal to cells (Drlica and Zhao, 1997). 5 Bacterial resistance As we suggested previously, knowing the mode of action of an antibacterial agent will help us to understand the way in which bacteria develop resistance, as the specific resistance mechanisms will be related to interference with the processes targeted by the antibacterial agent.

What cellular process the agents target in prokaryotic cells and how this differs from eukaryotic cells) and how bacteria will develop resistance to them. As you will have gathered from the title of this section, the quinolones exert their antibacterial activity by targeting DNA synthesis, so in order to understand how they do this, we need to look at the processes involved in DNA replication. We will also need to focus on how the quinolones can do this selectively in prokaryotic (bacterial) cells as, of course, this process will also be taking place in eukaryotic (mammalian) cells.

Download PDF sample

Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications by Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

by John

Rated 4.81 of 5 – based on 28 votes